Originally posted on December 8, 2011.

This will be a long review, for which I am not at all sorry. The existence of this post is a little bit of an accomplishment for me. In the search of authors to interview, I was introduced to Misha Angrist by his publicist. This was exciting for me, because it put me in touch with an interesting author and person. It was an experience I thoroughly enjoyed. At the same time I was discussing interviewing Misha, I was invited to review the book.

Much to my delight — and surprise — I got an actual copy for review. I’ve owned ARCs before, but never one that was sent to me, for me, for the purpose of reading critically. At least, not in actual, physical form.

I was delighted when it arrived, although it was a little worse for wear due to the rain. Fortunately, the book wasn’t damaged, although the packaging had seen its last days. It held on just long enough to get inside before it lost its ability to hold the book inside of it anymore. It did its job admirably!

Here is some information about the book before I start talking about it.

Paperback: 352 pages
Publisher: Harper Perennial; Reprint edition (November 8, 2011)
Language: English
ISBN-10: 0062074237
ISBN-13: 978-0062074232
Product Dimensions: 7.8 x 5.2 x 0.9 inches

 

This is the second print run of the book, with a new cover design. The original printing was in hardback.
This edition of the book has a modified introduction. I have not read the introduction of the original version, so I cannot tell you what the differences in these versions are.

After I got the book inside, I took it to my desk and sat down. Just like a kid in a candy store, I opened the book. I meant to just take a little peek, really.

I’m not sure how much time I lost due to this ‘peek’, but by the time I looked back up, I had read enough pages of the book to know I had misplaced time somewhere. I am not someone who goes out and reads a lot of science-related books. I was never good at math, and my level of science is limited to ‘don’t dump water over flaming oil’. If knowledge of science was a precursor for life, I would have been kicked off of the island long ago.

While I was waiting for this book to arrive, there were questions milling about in my brain — distracting, worrisome questions. Would I be smart enough for this book? Would I be able to understand what was going on? How much research would I need to do for this to make sense to me? Genes and genomes are big, big things. They are heavy science. They’re the stuff that people with doctorates talk about in shadowy corners where the plebeians can’t hear what is going on. And make no mistake, I’m just another plebeian of society, for all I like reading a good science fiction.

Perhaps this is the reason — this lack of knowledge, ignorance if you will — that when I opened this book, I didn’t get anything remotely what I expected from it. In fact, it starts off rather normal. It starts with the year that Misha was born.

I had expected some science that I would inevitably have to research just to understand what was going on.

Misha writes of the kind of person he is, and a little about the circumstances that brought this book to life. And by life, I do mean life. If you were to judge the book by the very first page, you would not believe Misha anymore than a simple, normal, average man. And I mean that in the best way possible. He is just another human being.

It is on page two that he begins talking about his mission, and the exposing of his genomes for the public eye. It begins, not a lecture on sciences, on DNA strands and proteins, but rather a story of a few amazing people who have ventured into gray territories to get a better understanding of humans and what separates a healthy human from one who suffers from a genetic disease.

I admit, I had to slow down as i read this book. It isn’t light reading material, but it is well-written, well-explained reading material that is understandable even by people like me who haven’t been in a science course for at least ten years. There were times I had to stop and reference the notes, or I had to refresh myself on some basic scientific principles, but many of the things that should have been confusing weren’t.

Like the stories of the people who’ve worked to make genomes accessible to the public, the story of the science of genomics, the history of the science, and the events that hampered the efforts are brought to light in a way that is easy to understand while being interesting to read.

But, best of all, it isn’t just a book about sciences. It is a book about people. Not all of the stories are happy. But, it shows just why this type of science is important, and served as food for thought for me. It also proved that there are really people behind the sciences, something that isn’t reflected in mass-group studies and most of the science-related news the public is exposed to.

Unlike fiction, I can’t really rate this book by characters or plot. The characters are real people. The plot is life. I will say I found it an interesting, well-written read. I can’t tell you if it stands up to other genomics books, because I haven’t read them. I don’t know how it will stand up against the scrutiny of science lovers and scientists.

Overall, I’m giving this book 4* — there were times where I was confused and had to do research to figure out just what was meant, and slips that are common knowledge for scientists and not so for the average person. The writing is stable and interesting, and Misha Angrist does a good job of bringing a healthy dose of humanity to his writing.

Recommendations: I would recommend this book to teenagers and adults. There is a certain level of science knowledge required, but it is (mostly) the stuff you learn in middle and high school. The only significant issue with this book I had was the high number of references found within it. For those who want to know what those references mean, it involves a great deal of flipping to the end of the book to find out just what is being referenced. It is a challenging read, but one I find well worth the effort. It provoked thought, as well as offered some hope that with access to more genomes available, more individuals will become interested in this form of science to help combat genetic diseases, as well as determine in advance if a youth is likely to develop certain diseases.

If you are interested in purchasing this title, you can do so here.

 

Originally posted on December 5, 2011.

Today is something special for my blog. I talk science fiction and fantasy often. But, despite the close-knit ties with world creation and sciences, I don’t often get to talk about actual science.

Book Cover
Here is a Human Being: At the Dawn of Personal Genomics

It is my pleasure to introduce to you Dr. Misha Angrist, the author of Here is a Human Being: At the Dawn of Personal Genomics. I read non-fiction often as a part of freelance writing. Research is necessary.

This has made me rather jaded to quite a bit of research material that once used to be very exciting. This book managed to catch my attention right from the start, and not only because of the subject matter.

While this book is much more fact than fiction, fact is what Science Fiction (and even Fantasy) is based off of. The question of ‘what if’ is a major part of speculative fiction, and without truth to back it, this genre of writing couldn’t even exist. Even the most far-fetched tales, after all, do include a glimmer of reality and truth.

Without further ado, on to the interview!

Misha, thank you for taking the time out of your busy schedule to answer these questions.  Can you please tell us a little about your book?

Thanks for having me, Rebecca! My book, Here is a Human Being: At the Dawn of Personal Genomics follows the rise of cheap DNA sequencing and its initial foray into research on human beings and its arrival in the marketplace. It asks what genomics is and why we should care: what can a person learn from her DNA sequence? It tells the stories of a number of people who have been involved in personal genomics from the ground up. It is a narrative nonfiction book that is part science, part journalism and part memoir.

I have heard that a lot of research scientists get into a specific branch due to personal events in their lives. Unfortunately, the rumor has it that these are tragedies. Is this true? What events in your life brought you to the point that you wanted to make a study of human genes and genomes, and volunteering yours for study?

Many years ago I trained as a genetic counselor. After that I did a PhD and a postdoc in genetics. For about eight years I studied a rare genetic disease of the intestinal tract called Hirschsprung disease. As fate would have it, my nephew was born with Hirschsprung disease in 2005. He is generally healthy but he has had multiple surgeries and he and his parents have been through a lot.

To be honest, my understanding of human genes and genomes is limited to ‘the instruction manual of living things’. Sciences aren’t pushed in schools as nearly as much as they should be. Can you give us a brief lesson on genes and genomes and why this area of study needs to be pursued by more scientists?

A genome is the complete DNA sequence of any organism. DNA is a code written in four letters: A, G, C and T. We speak of “the human genome” as a shorthand, but really, except for identical twins, every person’s genome is a little different from every other person’s. We get half of our 6 billion letters of DNA from our biological mother and half from our biological father. About 2% of our genome actually corresponds to genes–individual units of heredity–that code for proteins like collagen and hemoglobin. We don’t know what most of the rest of our DNA does. These are two of the great challenges: understanding what all that DNA does and understanding what all of the variation in our genome does.

Off of the top of your head, If you had to pick one scientifically accurate Science Fiction book relating to genes and genomes, which book would you pick? What is so accurate about this book? Do you feel that this book was ahead of its time?

That’s an excellent question…which I’m going to dodge. In literary fiction, I think Allegra Goodman’s Intuition really captures the life of a postdoc in a modern lab in a way that really hadn’t been told before. As far as more traditional science fiction goes, I think Jurassic Park is a fun thought experiment: what if we could clone dinosaurs? Scientifically there’s a lot of hand-waving (frog DNA etc), but it’s something that is still a plausible what-if question.

On the flip side of the coin, there are a lot of inaccurate Science Fiction novels relating to genes and genomes out there. What book do you feel is the worst offender, and why?

Gosh, I’d be hard-pressed to pick just one…Chromosome 6 is pretty ridiculous. And not to let Michael Crichton off the hook: Next is so over the top that you wonder if it shouldn’t have gone to straight to video. That said, I confess that I’m quite curious about Micro, which is the book Crichton was working on when he died and that was finished by Richard Preston, who, in my opinion, is a master.

We couldn’t talk about Science Fiction books and accuracy without repeating the process for movies. What one movie would you pick as the most scientifically accurate Science Fiction film?

My colleague David Goldstein and I show GATTACA to our nonmajors human genome class. There are a few liberties taken with the science, but again, it asks a question that is fair to ask: what if society were stratified based mainly on DNA? And the film asks it in a stylish and compelling way. The Boys from Brazil was ahead of its time as far as thinking about genetic determinism and environment. I would also put in a word for Ron Moore’s re-imagined Battlestar Galactica series, which grapples with what it means to be human and singlehandedly deconstructed so many of the reigning sci fi cliches.

Which film would win the prize for the worst offender?

Hoo boy. There are so many stinkers to choose from. Godsend comes to mind (it also raises the oft-asked question: what the hell happened to Robert De Niro?). Sphere with Dustin Hoffman babbling on incoherently is so bad that it’s almost good. And I suspect that Battlefield Earth didn’t win many converts to Scientology.

I have a little bit of a tradition of asking victims . . . er, volunteers a question to conclude an interview. Stuck on an empty island is overdone. You are trapped in an elevator and the emergency phone doesn’t work. You have one individual with you. This individual can be a super hero, an author, a mad scientist – anyone you want, dead or alive. Who would you want with you in the elevator and why? Would you pick someone to talk with, or would you escape? You’ve a world of possibilities!

I’m a bit claustrophobic so I’d probably pick someone with the skills to get me out. Houdini, perhaps? David Blaine? Probably the safest bet would be MacGyver.

Thank you very much for taking the time to answer these questions!

Thanks!

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